Anaphylaxis can develop in patients w/ undetectable IgA who have anti-IgA Abs; in patients w/ tolerance to previous human Ig treatment. Adverse reactions may occur more frequently in patients who receive human Ig for the 1st time or, in rare cases, when switching human Ig product or when there has been a long interval since the previous infusion; in patients w/ an untreated infection or underlying chronic inflammation. IVIg administration requires adequate hydration prior to initiation, monitoring of urine output & serum creatinine levels, & avoidance of concomitant loop diuretics. Thromboembolic events eg, MI, CVA (including stroke), pulmonary embolism & DVT; acute renal failure; aseptic meningitis syndrome occuring more frequently w/ high-dose (2 g/kg) IVIg treatment; haemolytic anaemia; neutropenia; acute non-cardiogenic pulmonary oedema (transfusion-related acute lung injury). Administer IVIg products at min infusion rate & dose practicable in patients at risk for thromboembolic adverse reactions &/or acute renal failure. Consider discontinuation in case of renal impairment. Monitor for clinical signs & symptoms of haemolysis. May result in misleading positive results in serological testing. Possibility of transmitting infective agents. Minor influence on the ability to drive & use machines. Pregnancy & lactation.